About letermovir
Cytomegalovirus antiviral
Used for
- Prevention of cytomegalovirus disease in certain high-risk adults after stem cell or kidney transplant.
Usual adult dose
480 mg intravenously once daily; reduce to 240 mg daily with cyclosporine.
Common side effects
- Nausea
- Diarrhea
- Vomiting
- Swelling of the arms or legs
Important warnings
- For prevention, not treatment of active cytomegalovirus infection.
- Dose changes are needed with cyclosporine.
- Infusion reactions can occur; follow the infusion rate instructions.
- Liver tests may need monitoring, especially with cyclosporine.
Pregnancy
Human pregnancy information is limited; use only when a clinician determines benefits outweigh potential risks.
Breastfeeding
It is not known whether letermovir passes into human milk; discuss risks with a healthcare professional.
Interactions
- Cyclosporine increases letermovir exposure and requires a lower dose.
- Rifampin and rifabutin can reduce letermovir levels; avoid use.
- Letermovir can reduce levels of voriconazole and several statins.
- Interactions may occur with transplant medicines, including tacrolimus and sirolimus.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.