About larotrectinib
TRK kinase inhibitor
Used for
- Treats certain solid tumors with an NTRK gene fusion.
- Used when cancer has spread or surgery could cause serious harm, and alternatives are unsatisfactory.
Usual adult dose
100 mg by mouth twice daily; dosing may be adjusted for side effects or liver problems.
Usual dose in children
100 mg/m² by mouth twice daily, maximum 100 mg per dose; dosing may be adjusted.
Common side effects
- Tiredness
- Dizziness
- Nausea or vomiting
- Constipation or diarrhea
Important warnings
- Can cause nervous system effects, including dizziness, confusion, or coordination problems.
- May cause liver injury; liver blood tests are monitored.
- May cause fetal harm; effective contraception is recommended during treatment.
- Dose changes may be needed with liver impairment or interacting medicines.
Pregnancy
May harm an unborn baby. Human pregnancy data are limited.
Breastfeeding
Breastfeeding is not recommended during treatment and for one week after the final dose.
Interactions
- Strong CYP3A inhibitors can increase larotrectinib levels.
- Strong CYP3A inducers can reduce larotrectinib levels.
- Larotrectinib can increase levels of some CYP3A substrates, including certain sedatives and statins.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.