About ixazomib
Oral proteasome inhibitor
Used for
- Used with lenalidomide and dexamethasone to treat multiple myeloma in adults previously treated with at least one therapy.
Usual adult dose
4 mg by mouth once weekly on days 1, 8, and 15 of each 28-day cycle, with lenalidomide and dexamethasone.
Common side effects
- Diarrhea, constipation, nausea, or vomiting
- Low platelet counts
- Rash
- Nerve problems, such as numbness or tingling
Important warnings
- Can cause low platelet counts, serious infections, or nerve damage.
- Rarely causes severe skin reactions or liver problems.
- Take capsules on an empty stomach; swallow whole.
- Embryo-fetal harm is possible; follow contraception precautions during treatment.
Pregnancy
May harm an unborn baby. Avoid pregnancy during treatment and for 90 days after the last dose; men should use contraception for 90 days afterward.
Breastfeeding
Breastfeeding is not recommended during treatment or for 90 days after the final dose.
Interactions
- Strong CYP3A inducers, such as rifampin, may reduce ixazomib levels and effectiveness.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.