About ixazomib
Oral proteasome inhibitor
Used for
- Treats multiple myeloma with lenalidomide and dexamethasone, usually after at least one prior treatment.
Usual adult dose
Usually 4 mg by mouth once weekly on days 1, 8, and 15 of a 28-day cycle, with lenalidomide and dexamethasone; dose adjustments may be needed.
Common side effects
- Diarrhea, constipation, nausea, and vomiting
- Low platelet counts and increased bruising or bleeding
- Nerve damage causing numbness, tingling, or pain
- Rash and swelling
Important warnings
- Can cause low blood counts, severe infection, or bleeding.
- May cause peripheral neuropathy, liver problems, or severe skin reactions.
- Can harm an unborn baby; effective contraception is required during treatment.
- Swallow capsules whole; do not open, crush, or chew them.
Pregnancy
May cause fetal harm. Avoid pregnancy during treatment and for 90 days after the last dose; follow contraception guidance.
Breastfeeding
Do not breastfeed during treatment or for 90 days after the last dose.
Interactions
- Strong CYP3A inducers, such as rifampin or St. John’s wort, can reduce ixazomib levels.
- Strong CYP3A inhibitors, such as clarithromycin, may increase ixazomib levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.