About ivabradine
Heart-rate-lowering medicine
Used for
- Chronic heart failure in suitable adults
- Long-term treatment of stable angina in suitable adults
Usual adult dose
Usually 5 mg twice daily with meals; adjusted according to heart rate and indication.
Common side effects
- Slow heart rate
- Temporary visual brightness or flashes
- Dizziness
- Headache
Important warnings
- Can cause an excessively slow or irregular heartbeat.
- Not suitable during pregnancy or breastfeeding.
- Avoid grapefruit and grapefruit juice.
- Heart rate and heart rhythm should be monitored.
Pregnancy
Avoid during pregnancy; human safety information is limited, and animal studies indicate possible harm.
Breastfeeding
Not recommended; it is unknown whether ivabradine passes into human milk.
Interactions
- Strong CYP3A4 inhibitors, including clarithromycin and ketoconazole, can raise ivabradine levels.
- Verapamil and diltiazem increase exposure and slow heart rate; avoid combination.
- Other heart-rate-lowering medicines can increase risk of slow heartbeat.
- Avoid grapefruit juice, which can increase medicine levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.