About isotretinoin
Oral retinoid
Used for
- Severe acne that has not responded adequately to other treatments
Usual adult dose
Usually 0.5–1 mg/kg daily in one or two doses for about 15–20 weeks; specialist-directed.
Common side effects
- Dry lips, skin, eyes, and nose
- Muscle or joint aches
- Raised blood fats or liver enzymes
- Headache or mood changes
Important warnings
- Can cause severe birth defects; strict pregnancy-prevention measures are required.
- Do not donate blood during treatment or for one month afterward.
- Seek urgent care for severe headache, vision changes, or major mood changes.
- Avoid vitamin A supplements and limit sun exposure.
Pregnancy
Must not be used during pregnancy. It can cause severe birth defects; pregnancy testing and prevention requirements apply.
Breastfeeding
Avoid during breastfeeding; the medicine may harm a nursing infant.
Interactions
- Tetracycline antibiotics can increase risk of raised pressure in the brain.
- Vitamin A supplements can increase toxicity.
- Avoid other acne medicines that irritate or dry the skin unless prescribed.
- Alcohol may worsen increased blood fats or liver effects.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.