About isosorbide dinitrate
Nitrate vasodilator
Used for
- Acute heart failure, including after a heart attack
- Severe angina when treatment by infusion is needed
- High blood pressure during heart surgery
Usual adult dose
Intravenous infusion usually starts at 2–10 mg/hour, adjusted to response and blood pressure; specialist supervision required.
Common side effects
- Headache
- Dizziness or faintness
- Low blood pressure
- Nausea
Important warnings
- Must be given by controlled infusion with blood pressure monitoring.
- Can cause severe low blood pressure, especially with dehydration or other blood-pressure-lowering medicines.
- Do not use with sildenafil, tadalafil, vardenafil, or riociguat.
- Avoid in shock, severe anemia, or raised pressure inside the skull.
Pregnancy
Use only when clearly needed; evidence is limited and a clinician should weigh benefits and risks.
Breastfeeding
Information is limited; use only with clinical advice, considering potential effects on the infant.
Interactions
- Sildenafil, tadalafil, and vardenafil can cause dangerous blood-pressure drops.
- Riociguat can cause dangerous blood-pressure drops.
- Other nitrates or blood-pressure-lowering medicines may increase hypotension.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.