About isavuconazonium sulfate
Triazole antifungal
Used for
- Treats invasive aspergillosis in adults.
- Treats invasive mucormycosis in adults.
Usual adult dose
Loading: 200 mg isavuconazole every 8 hours for six doses; then 200 mg once daily, by intravenous infusion.
Common side effects
- Nausea, vomiting, diarrhea, or abdominal pain
- Headache
- Elevated liver enzymes
- Low potassium
Important warnings
- Can cause liver injury; liver tests may be monitored.
- May shorten the QT interval; avoid in familial short-QT syndrome.
- Can cause serious allergic or infusion reactions.
- Strong CYP3A4 interactions can change drug levels; some combinations are contraindicated.
Pregnancy
May harm the fetus based on animal studies; use during pregnancy only when clearly needed.
Breastfeeding
Unknown whether it passes into breast milk; benefits and risks should be considered.
Interactions
- Avoid strong CYP3A4 inhibitors, such as ketoconazole or high-dose ritonavir.
- Avoid strong CYP3A4 inducers, such as rifampin or carbamazepine.
- Can reduce levels of tacrolimus, sirolimus, and cyclosporine; monitoring may be needed.
- Can increase levels of some CYP3A4-metabolized medicines, including atorvastatin.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.