About isavuconazole
Triazole antifungal
Used for
- Treats invasive aspergillosis in adults.
- Treats invasive mucormycosis in adults.
Usual adult dose
Loading: 200 mg every 8 hours for 6 doses. Then 200 mg once daily, by infusion.
Common side effects
- Nausea, vomiting, or diarrhea
- Liver-test abnormalities
- Low potassium
- Infusion reactions
Important warnings
- Can cause serious liver problems; monitor liver tests.
- May shorten the QT interval; avoid in familial short QT syndrome.
- Many medicines interact; some combinations are contraindicated.
- Use caution with severe liver impairment.
Pregnancy
May harm an unborn baby; use during pregnancy only when clearly needed.
Breastfeeding
It is unknown whether isavuconazole passes into breast milk; discuss risks with a healthcare professional.
Interactions
- Strong CYP3A4 inhibitors or inducers can substantially alter isavuconazole levels.
- Avoid rifampin, carbamazepine, St. John’s wort, and high-dose ritonavir.
- Can increase levels of tacrolimus, sirolimus, and cyclosporine; monitoring may be needed.
- Can reduce levels of some CYP3A4 substrates, including midazolam.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.