About isavuconaz ole
Triazole antifungal
Used for
- Treats invasive aspergillosis in adults.
- Treats invasive mucormycosis in adults.
Usual adult dose
200 mg every 8 hours for six doses, then 200 mg once daily. Dose is expressed as isavuconazole.
Common side effects
- Nausea, vomiting, diarrhoea, or abdominal pain
- Headache
- Raised liver enzymes
- Low potassium
Important warnings
- Can cause serious liver problems; liver tests may be monitored.
- Shortens the QT interval and is unsuitable for familial short-QT syndrome.
- Avoid in pregnancy; effective contraception is advised during treatment and for one month afterward.
- Capsules must be swallowed whole; do not crush or chew.
Pregnancy
Avoid during pregnancy because of potential fetal harm; human safety information is limited.
Breastfeeding
It is not known whether isavuconazole passes into breast milk; discuss risks with a healthcare professional.
Interactions
- Strong CYP3A4 inhibitors, such as ketoconazole, can greatly increase levels.
- Strong CYP3A4 inducers, such as rifampicin or carbamazepine, can reduce levels; avoid combination.
- May increase levels of medicines including tacrolimus, sirolimus, and cyclosporine.
- Can reduce effectiveness of hormonal contraceptives; use additional non-hormonal contraception.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.