About iptacopan
Complement factor B inhibitor
Used for
- Treats paroxysmal nocturnal hemoglobinuria (PNH) in adults.
- Treats C3 glomerulopathy (C3G) in adults, including reducing proteinuria.
Usual adult dose
PNH: 200 mg by mouth twice daily. C3G: 200 mg twice daily.
Common side effects
- Upper respiratory infections
- Headache
- Diarrhea
- Abdominal pain or nausea
Important warnings
- Can cause serious infections, especially from encapsulated bacteria; vaccination is required.
- Do not start during a serious infection with encapsulated bacteria.
- Stopping treatment can worsen PNH or C3G; monitor for relapse.
- May increase cholesterol and triglycerides.
Pregnancy
Human pregnancy data are limited. Use only when potential benefit justifies potential fetal risk.
Breastfeeding
It is unknown whether iptacopan passes into breast milk. Discuss feeding plans with a clinician.
Interactions
- Strong CYP2C8 inhibitors, such as gemfibrozil, can increase iptacopan exposure.
- Strong CYP2C8 inducers, such as rifampin, can reduce iptacopan exposure.
- Iptacopan may increase levels of CYP2C8 substrates, such as repaglinide.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.