About imipenem monohydr ate
Carbapenem antibiotic combination
Used for
- Treats serious infections caused by susceptible bacteria, including abdominal, urinary, lung, skin, and bloodstream infections.
Usual adult dose
Usually 500 mg imipenem every 6 hours by intravenous infusion; dose varies with infection and kidney function.
Usual dose in children
For children aged 3 months and older: usually 15–25 mg imipenem/kg every 6 hours intravenously; specialist dosing is required.
Common side effects
- Nausea, vomiting, or diarrhoea
- Rash or other allergic reactions
- Pain or inflammation at the infusion site
- Seizures, especially with kidney problems or high doses
Important warnings
- Not effective against viral infections.
- Dose adjustment is needed in impaired kidney function.
- Seizure risk is higher with kidney impairment or nervous-system disorders.
- Serious allergy can occur, especially with previous beta-lactam antibiotic allergy.
Pregnancy
Use during pregnancy only when clearly needed; evidence is limited, so the prescriber weighs benefits and risks.
Breastfeeding
Small amounts may enter breast milk. Monitor the infant for diarrhoea, thrush, or rash.
Interactions
- Valproate: imipenem can lower levels and increase seizure risk.
- Ganciclovir: may increase seizure risk.
- Warfarin: antibiotic treatment may alter blood-clotting measurements.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.