About imatinib as mesilate
Tyrosine kinase inhibitor
Used for
- Treats chronic myeloid leukemia (CML) and some acute lymphoblastic leukemia (ALL).
- Treats gastrointestinal stromal tumors (GIST) and certain other rare cancers.
Usual adult dose
Often 400 mg once daily for CML or GIST; some conditions need different doses.
Usual dose in children
For selected childhood leukemias, commonly 340 mg/m² once daily; specialist-directed dosing varies.
Common side effects
- Nausea, diarrhea, muscle cramps, and fatigue
- Swelling or fluid retention
- Rash and abdominal discomfort
- Low blood counts
Important warnings
- Can cause serious liver injury and severe fluid retention.
- Blood counts and liver function require monitoring.
- May cause fetal harm; effective contraception is important during treatment.
- Take with food and a large glass of water to reduce stomach irritation.
Pregnancy
May harm the fetus. Avoid during pregnancy unless a specialist determines treatment is essential.
Breastfeeding
Breastfeeding is not recommended during treatment and for at least one month after the last dose.
Interactions
- Strong CYP3A4 inhibitors or inducers can alter imatinib levels.
- Warfarin and some other medicines may increase bleeding risk or interact.
- Avoid grapefruit, which may affect imatinib levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.