About ifosfamide
Alkylating chemotherapy medicine
Used for
- Treats testicular cancer, sarcomas, and other cancers, usually with other medicines.
Usual adult dose
Varies by cancer and regimen; commonly 1.2 g/m² intravenously daily for five days per cycle.
Usual dose in children
Specialist-directed dosing by body surface area; regimens vary by cancer.
Common side effects
- Low blood cell counts, infection, or bleeding
- Nausea, vomiting, and hair loss
- Bladder irritation or bleeding
- Confusion, sleepiness, or other brain effects
Important warnings
- Given under specialist supervision, often in hospital.
- Mesna and fluids are used to reduce bladder injury.
- Can cause severe bone marrow suppression and serious infections.
- May impair fertility and harm an unborn baby.
Pregnancy
Can cause fetal harm. Avoid during pregnancy; effective contraception is needed during treatment and for a period afterward.
Breastfeeding
Breastfeeding is not recommended during treatment and for at least one week after the last dose.
Interactions
- Other medicines that suppress bone marrow can increase infection and bleeding risks.
- Some medicines affecting liver enzymes may alter ifosfamide effects or toxicity.
- Live vaccines may cause infection during treatment.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.