About ibuprofen + diphenhydramine
NSAID and sedating antihistamine
Used for
- Short-term relief of pain that interferes with sleep.
- Nighttime relief of occasional aches, pains, and difficulty sleeping.
Usual adult dose
Adults and children 12 years and older: 2 tablets at bedtime; do not exceed 2 tablets in 24 hours.
Common side effects
- Drowsiness
- Dizziness
- Upset stomach or heartburn
- Dry mouth
Important warnings
- May cause marked drowsiness; avoid alcohol and driving.
- Can cause stomach bleeding, kidney problems, or allergic reactions.
- Avoid with other ibuprofen, NSAIDs, or diphenhydramine products.
- Not for children under 12; use only briefly for occasional sleeplessness.
Pregnancy
Avoid from 20 weeks of pregnancy unless specifically directed; avoid after 30 weeks. Diphenhydramine use should be discussed with a clinician.
Breastfeeding
Ibuprofen is generally compatible with breastfeeding; diphenhydramine may cause infant drowsiness or reduce milk supply, especially with repeated use.
Interactions
- Blood thinners and antiplatelet medicines may increase bleeding.
- Other NSAIDs increase stomach and kidney risks.
- Alcohol, sedatives, and opioids increase drowsiness.
- Anticholinergic medicines may worsen dry mouth, constipation, or urinary retention.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.