About hydrocortisone as sodium succinate
Corticosteroid hormone replacement
Used for
- Replacement therapy for adrenal insufficiency
- Treatment of severe allergic and inflammatory conditions
- Short-term treatment of selected autoimmune disorders
Usual adult dose
Adrenal insufficiency: commonly 15–25 mg daily in divided doses; other conditions vary widely.
Usual dose in children
Adrenal insufficiency: commonly 8–10 mg/m² daily in three divided doses; specialist adjustment is needed.
Common side effects
- Stomach upset, increased appetite, or weight gain
- Mood changes, sleep problems, or headache
- Raised blood sugar or blood pressure
- Increased infection risk and weakened bones with prolonged use
Important warnings
- Do not stop long-term treatment suddenly; dose reduction may be needed.
- Illness, injury, or surgery may require a temporary dose increase.
- Can mask infections and worsen some infections.
- Long-term use may affect growth in children and bone strength.
Pregnancy
May be used when clinically needed; the prescriber should review treatment during pregnancy.
Breastfeeding
Generally compatible at usual replacement doses; higher or prolonged doses may require infant monitoring.
Interactions
- Rifampicin, phenytoin, and carbamazepine may reduce hydrocortisone effects.
- Ritonavir and some antifungals may increase hydrocortisone effects.
- NSAIDs may increase stomach ulcer or bleeding risk.
- Warfarin effects may change and require monitoring.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.