About human hepatitis b immunoglo
Human hepatitis B immunoglobulin
Used for
- Prevention of hepatitis B after exposure, including needlestick injuries
- Prevention of hepatitis B in newborns of infected mothers
- Prevention of infection after liver transplantation
Usual adult dose
Dose depends on exposure and vaccination status; commonly 500–1,000 IU intramuscularly after exposure. Transplant prevention uses specialist-directed intravenous dosing.
Usual dose in children
Newborns of infected mothers commonly receive 30–100 IU intramuscularly soon after birth, with hepatitis B vaccine.
Common side effects
- Injection-site pain or tenderness
- Headache or feeling unwell
- Allergic reactions, rarely severe
- Rare risk of blood-product-transmitted infection
Important warnings
- Give promptly after exposure; it does not replace hepatitis B vaccination.
- Do not inject into a vein when given intramuscularly.
- May interfere with live vaccines, including measles and rubella vaccines.
- Use caution with severe immunoglobulin allergy or IgA deficiency.
Pregnancy
May be used when needed to prevent hepatitis B; a clinician should assess the circumstances.
Breastfeeding
Generally compatible with breastfeeding; preventing hepatitis B transmission is important.
Interactions
- May reduce responses to live vaccines; delay them as directed by a clinician.
- Tell the vaccinating clinician, as hepatitis B vaccine should also be given when indicated.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.