About guanethidine monosulfate
Adrenergic neuron-blocking antihypertensive
Used for
- Historically used to treat high blood pressure.
Usual adult dose
Dosing varies; injectable guanethidine is not a usual modern treatment. No standard current injection dose can be stated.
Common side effects
- Dizziness, weakness, and fainting from low blood pressure
- Slow heartbeat
- Diarrhea
- Nasal congestion
Important warnings
- May cause severe blood-pressure drops, especially on standing.
- Can slow the heartbeat and worsen heart failure.
- Use is limited; injectable dosing requires specialist supervision.
Pregnancy
Safety information is limited; use only when a clinician determines it is necessary.
Breastfeeding
Information is limited; a clinician should assess whether treatment is appropriate.
Interactions
- Stimulants such as amphetamines may reduce its blood-pressure effect.
- Tricyclic antidepressants and other medicines affecting nerve signaling can alter its effect.
- Other blood-pressure medicines can increase the risk of low blood pressure.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.