About granisetr on transderm
Serotonin 5-HT3 receptor antagonist
Used for
- Prevents nausea and vomiting from moderately or highly emetogenic chemotherapy.
Usual adult dose
Apply one patch 24–48 hours before chemotherapy; leave on for up to seven days.
Common side effects
- Constipation
- Headache
- Skin irritation or rash
- Abdominal pain
Important warnings
- May cause serotonin syndrome, especially with other serotonergic medicines.
- Can affect heart rhythm; caution with heart-rhythm disorders or certain medicines.
- Remove before MRI, cardioversion, or defibrillation because the patch contains aluminum.
- Avoid exposing the patch to external heat, which can increase medicine absorption.
Pregnancy
Human pregnancy data are limited; use only when clearly needed.
Breastfeeding
It is unknown whether granisetron passes into breast milk; consider benefits and potential risks.
Interactions
- Serotonergic medicines, including some antidepressants, may increase serotonin syndrome risk.
- Medicines that prolong the QT interval may increase heart-rhythm risks.
- Strong CYP3A4 enzyme inducers may reduce granisetron exposure.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.