About granisetr on
5-HT3 serotonin receptor antagonist
Used for
- Prevention and treatment of nausea and vomiting caused by chemotherapy or radiotherapy
- Prevention and treatment of postoperative nausea and vomiting
Usual adult dose
Usually 1 mg intravenously before chemotherapy or radiotherapy; postoperative dosing is usually 1 mg intravenously.
Usual dose in children
For children aged 2 years and older receiving chemotherapy, usually 10–40 micrograms/kg intravenously, up to 3 mg.
Common side effects
- Headache
- Constipation
- Diarrhoea
- Raised liver enzyme levels
Important warnings
- May affect heart rhythm, especially with existing heart problems or electrolyte imbalance
- Can mask signs of bowel obstruction
- Rarely causes severe allergic reactions
- Serotonin syndrome is possible with other medicines affecting serotonin
Pregnancy
Use during pregnancy only when clearly needed; human safety information is limited.
Breastfeeding
It is not known whether granisetron passes into breast milk; breastfeeding decisions require clinical assessment.
Interactions
- Other medicines that prolong the QT interval may increase heart rhythm risks
- Serotonergic medicines, including some antidepressants, may increase serotonin syndrome risk
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.