About glycerol phenylbut yrate
Ammonia-scavenging nitrogen-binding agent
Used for
- Long-term treatment of urea cycle disorders when dietary protein restriction and supplements are insufficient.
- Used with dietary and other treatments; not for acute high-ammonia emergencies.
Usual adult dose
Individualized by body surface area or weight and blood ammonia; usually divided into three or more doses daily with food.
Usual dose in children
Individualized by body surface area or weight and blood ammonia; used in children, including infants, in divided daily doses with food.
Common side effects
- Diarrhea, nausea, vomiting, or abdominal pain
- Headache, dizziness, or tiredness
- Reduced appetite or gas
- Unusual body odor or taste changes
Important warnings
- Requires specialist monitoring of blood ammonia, amino acids, electrolytes, and liver function.
- Not suitable for emergency treatment of dangerously high ammonia.
- Use caution with liver or kidney impairment and pancreatic insufficiency.
- Do not stop or change treatment without medical supervision.
Pregnancy
Human pregnancy information is limited; use requires careful consideration of benefits and risks by a specialist.
Breastfeeding
It is not known whether the medicine passes into breast milk; specialist guidance is needed.
Interactions
- Probenecid may affect removal of the medicine’s metabolites.
- Corticosteroids, valproate, and haloperidol may increase ammonia levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.