About glimepride + metformin
Sulfonylurea and biguanide combination
Used for
- Type 2 diabetes, alongside diet and exercise, when both medicines are appropriate.
Usual adult dose
Often one tablet once or twice daily with meals; dose is individualized and adjusted using blood sugar and kidney function.
Common side effects
- Low blood sugar
- Nausea, diarrhea, or stomach discomfort
- Metallic taste
- Vitamin B12 deficiency with long-term use
Important warnings
- Not for type 1 diabetes or diabetic ketoacidosis.
- Rarely, metformin can cause serious lactic acidosis, especially with severe kidney problems.
- Glimepiride may cause severe low blood sugar, particularly with missed meals.
- Kidney function and blood sugar require monitoring.
Pregnancy
Diabetes treatment in pregnancy needs clinician oversight; insulin is commonly preferred. This combination may not be suitable.
Breastfeeding
Metformin enters breast milk in small amounts; glimepiride may affect a nursing infant. A clinician should review treatment.
Interactions
- Insulin and other diabetes medicines can increase low blood sugar risk.
- Some antibiotics, antifungals, and blood pressure medicines can alter blood sugar or glimepiride effects.
- Alcohol can increase low blood sugar and lactic acidosis risks.
- Iodinated contrast procedures may require temporarily stopping metformin.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.