About glyburide + metformin hcl
Sulfonylurea and biguanide antidiabetic
Used for
- Treats type 2 diabetes alongside diet and exercise.
- Helps lower blood glucose when one medicine alone is insufficient.
Usual adult dose
Usually one tablet once or twice daily with meals; adjusted gradually to blood glucose and tolerability.
Common side effects
- Low blood sugar
- Diarrhea, nausea, or stomach discomfort
- Metallic taste
- Vitamin B12 deficiency with long-term use
Important warnings
- Not for type 1 diabetes or diabetic ketoacidosis.
- Rarely, metformin can cause serious lactic acidosis, especially with kidney problems or severe illness.
- Glibenclamide can cause prolonged or severe low blood sugar.
- Kidney function and blood glucose require monitoring.
Pregnancy
Generally not preferred during pregnancy; insulin is commonly used. Treatment should be reviewed by a clinician.
Breastfeeding
Use requires clinician review; glibenclamide may pose a risk of low blood sugar in the infant.
Interactions
- Alcohol can increase side effects and lactic acidosis risk.
- Insulin and other diabetes medicines can increase low blood sugar.
- Some antibiotics, antifungals, and blood pressure medicines can alter glucose or glibenclamide effects.
- Iodinated contrast procedures may require temporarily stopping metformin.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.