About glasdegib
Hedgehog pathway inhibitor
Used for
- Used with low-dose cytarabine for newly diagnosed acute myeloid leukemia in adults unable to receive intensive chemotherapy.
Usual adult dose
100 mg by mouth once daily with low-dose cytarabine, continued until disease progression or unacceptable toxicity.
Common side effects
- Anemia, low platelet count, and low white blood cell count
- Muscle spasms and muscle or bone pain
- Nausea, diarrhea, and reduced appetite
- Changes in taste or abnormal heart rhythm
Important warnings
- Can cause serious birth defects or fetal death; pregnancy prevention requirements apply.
- Can prolong the QT interval and cause potentially dangerous heart rhythms.
- Monitor blood counts, electrolytes, kidney function, and muscle symptoms.
- Avoid strong CYP3A inhibitors when possible; review interacting medicines.
Pregnancy
Can cause fetal harm. Do not use during pregnancy; required pregnancy testing and contraception apply.
Breastfeeding
Breastfeeding is not recommended during treatment or for at least one week after the last dose.
Interactions
- Strong CYP3A inhibitors can increase glasdegib exposure.
- Strong CYP3A inducers can reduce glasdegib exposure.
- Medicines that prolong QT may increase abnormal heart rhythm risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.