About givinostat
Histone deacetylase inhibitor
Used for
- Treats Duchenne muscular dystrophy in patients aged 6 years and older.
Usual adult dose
Not established for adults; dosing is based on body weight and taken twice daily.
Usual dose in children
Ages 6 years and older: twice daily with food. Dose is based on weight and adjusted by a clinician.
Common side effects
- Diarrhea
- Nausea or vomiting
- Abdominal pain
- Low platelet count
Important warnings
- Blood counts and triglycerides require monitoring during treatment.
- May cause low platelet counts, which can increase bleeding risk.
- Diarrhea and vomiting can cause dehydration.
- Avoid live vaccines during treatment.
Pregnancy
May harm an unborn baby; pregnancy status should be checked before treatment.
Breastfeeding
It is not known whether givinostat passes into breast milk; breastfeeding is generally avoided during treatment.
Interactions
- Medicines that prolong the QT interval may increase abnormal heart-rhythm risk.
- Strong CYP3A4 inhibitors or inducers may affect givinostat levels.
- Other medicines that lower blood cells may increase blood-count problems.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.