About fosaprepitant dimeglumine
Neurokinin-1 receptor antagonist
Used for
- Prevents nausea and vomiting caused by chemotherapy, alongside other anti-sickness medicines.
Usual adult dose
115 mg by intravenous infusion about 30 minutes before chemotherapy, with other anti-sickness medicines.
Usual dose in children
For children aged 6 months and older, dosing is based on weight and chemotherapy regimen; use with other anti-sickness medicines.
Common side effects
- Tiredness or weakness
- Diarrhoea or indigestion
- Injection-site pain or irritation
- Raised liver enzyme levels
Important warnings
- Serious allergic reactions can occur during or after infusion.
- Can reduce hormonal contraceptive effectiveness during treatment and for one month afterwards.
- Use caution with severe liver problems.
- Not used to treat existing nausea or vomiting.
Pregnancy
Use only when clearly needed; pregnancy data are limited. Hormonal contraception may be less effective during treatment and for one month afterwards.
Breastfeeding
It is not known whether this medicine passes into breast milk; discuss the benefits and risks with a healthcare professional.
Interactions
- May reduce hormonal contraceptive effectiveness.
- Do not use with pimozide.
- Can alter levels of warfarin, some cancer medicines, and other medicines processed by CYP3A4.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.