About fomepizole
Alcohol dehydrogenase inhibitor antidote
Used for
- Treatment of ethylene glycol poisoning
- Treatment of methanol poisoning
Usual adult dose
15 mg/kg intravenously, followed by 10 mg/kg every 12 hours; dosing changes during prolonged treatment.
Usual dose in children
Same weight-based intravenous dosing as adults.
Common side effects
- Headache
- Nausea
- Dizziness
- Injection-site reactions
Important warnings
- For use under hospital supervision with laboratory monitoring.
- Hemodialysis may be needed for severe poisoning.
- Dose adjustments are needed during prolonged treatment or hemodialysis.
Pregnancy
Use for serious poisoning when needed; evidence in pregnancy is limited.
Breastfeeding
Breastfeeding safety is uncertain; clinical guidance is needed during treatment.
Interactions
- May affect alcohol breakdown and increase acetaldehyde after alcohol exposure.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.