About flucytosine
Antifungal antimetabolite
Used for
- Serious Candida infections, often combined with another antifungal
- Cryptococcal meningitis, usually combined with amphotericin B
Usual adult dose
Usually 25 mg/kg by mouth every 6 hours; adjust for kidney function and blood levels.
Usual dose in children
Specialist dosing is weight-based, usually 25 mg/kg by mouth every 6 hours; adjust for kidney function.
Common side effects
- Nausea, vomiting, diarrhea, or abdominal pain
- Low blood cell counts
- Liver enzyme changes
- Rash
Important warnings
- Can cause severe bone marrow suppression and liver toxicity; blood tests are needed.
- Dose adjustment and monitoring are important with kidney impairment.
- Treatment should be supervised by an experienced clinician.
- Resistance can develop when used alone for serious infections.
Pregnancy
Human pregnancy data are limited; potential fetal harm is a concern. Use only when benefits outweigh risks.
Breastfeeding
It is unknown whether flucytosine passes into breast milk; breastfeeding decisions require clinical assessment.
Interactions
- Amphotericin B may worsen kidney function, affecting flucytosine levels.
- Medicines that suppress bone marrow may increase blood-cell risks.
- Cytarabine may reduce flucytosine's antifungal effect.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.