About fluconazo le bp
Triazole antifungal
Used for
- Candida infections, including bloodstream infections
- Cryptococcal meningitis
- Prevention of fungal infections in selected high-risk patients
Usual adult dose
Usually 200–400 mg intravenously once daily, depending on infection. Invasive candidiasis: 800 mg initially, then 400 mg daily.
Usual dose in children
Usually 3–12 mg/kg intravenously once daily, depending on infection. Loading doses may be needed; newborns require longer intervals between doses.
Common side effects
- Nausea, vomiting, abdominal pain, or diarrhea
- Headache
- Rash
- Raised liver enzymes
Important warnings
- Rarely causes serious liver injury or severe skin reactions
- May cause dangerous heart rhythm changes
- Dose adjustment is often required for reduced kidney function
- Avoid with known fluconazole allergy
Pregnancy
Generally avoided during pregnancy unless necessary for serious infections. Prolonged high-dose treatment can cause birth defects.
Breastfeeding
Generally compatible with breastfeeding; small amounts enter breast milk. Infant diarrhea or other stomach upset may occur.
Interactions
- Warfarin: increased bleeding risk
- Phenytoin: increased drug levels
- Sulfonylurea diabetes medicines: increased risk of low blood sugar
- Certain heart rhythm medicines: increased risk of dangerous arrhythmias
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.