About fezolinetant
Neurokinin-3 receptor antagonist
Used for
- Reduces moderate to severe hot flashes associated with menopause.
Usual adult dose
45 mg by mouth once daily, with or without food.
Common side effects
- Abdominal pain
- Diarrhea
- Difficulty sleeping
- Elevated liver enzymes
Important warnings
- Liver injury, including rare serious cases, has occurred.
- Liver blood tests are needed before treatment and during treatment.
- Stop and seek medical assessment for jaundice, dark urine, or severe fatigue.
- Not recommended with cirrhosis or severe kidney impairment.
Pregnancy
Not indicated during pregnancy; safety is not established.
Breastfeeding
Safety is not established; use during breastfeeding is not recommended.
Interactions
- CYP1A2 inhibitors, such as fluvoxamine or ciprofloxacin, can raise fezolinetant levels.
- Avoid moderate or strong CYP1A2 inhibitors.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.