About fentanyl citrate
Opioid analgesic; sublingual fentanyl
Used for
- Breakthrough cancer pain in adults already receiving and tolerant to regular opioid therapy
Usual adult dose
Start with 100 micrograms under the tongue; adjust individually under specialist supervision. Repeat only as directed, with at least two hours between episodes.
Common side effects
- Nausea or vomiting
- Drowsiness, dizziness, or headache
- Constipation
- Breathing slowed or dangerously suppressed
Important warnings
- Only for opioid-tolerant adults with cancer breakthrough pain; not for other pain.
- Can cause fatal respiratory depression, especially with alcohol, sedatives, or incorrect use.
- Risk of dependence, misuse, and accidental poisoning; keep securely away from children.
- Avoid switching between fentanyl products without medical supervision; dosing may differ.
Pregnancy
May cause newborn withdrawal with prolonged use; use only when clinically necessary. Use during labour can depress a newborn’s breathing.
Breastfeeding
Not recommended during treatment or for at least five days after the last dose; fentanyl may harm a nursing infant.
Interactions
- Benzodiazepines, alcohol, and other sedatives increase sedation and breathing risks.
- CYP3A4 inhibitors, such as clarithromycin, may raise fentanyl levels.
- CYP3A4 inducers, such as rifampicin, may lower fentanyl levels.
- MAO inhibitors may cause serious reactions; avoid use during treatment and for 14 days afterward.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.