About fenofibrate + simvastatin
Fibrate and statin combination
Used for
- Treats high cholesterol and triglycerides in selected adults when one medicine alone is insufficient.
Usual adult dose
One tablet once daily with food, usually with the evening meal.
Common side effects
- Muscle pain or weakness
- Stomach discomfort, nausea, or diarrhoea
- Raised liver enzymes
- Headache
Important warnings
- Rarely causes serious muscle injury; risk rises with certain medicines and kidney problems.
- Can affect the liver, kidneys, and gallbladder; monitoring may be needed.
- Avoid with active liver disease or severe kidney impairment.
- Seek urgent care for severe muscle pain, weakness, or dark urine.
Pregnancy
Do not use during pregnancy; simvastatin is contraindicated, and fenofibrate is generally avoided.
Breastfeeding
Do not use while breastfeeding; simvastatin is contraindicated and fenofibrate is not recommended.
Interactions
- Avoid cyclosporine, gemfibrozil, and strong CYP3A4 inhibitors, such as clarithromycin.
- Some antivirals, antifungals, and heart medicines increase muscle-injury risk.
- Warfarin may require closer blood-clotting monitoring.
- Other cholesterol medicines and colchicine can increase muscle problems.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.