About factor xiii
Blood-clotting factor XIII replacement
Used for
- Treats congenital factor XIII deficiency and prevents bleeding.
- May be used for acquired factor XIII deficiency in specialist care.
- Supports healing after surgery in people with congenital deficiency.
Usual adult dose
Congenital deficiency: usually 40 IU/kg by intravenous injection every 28 days; adjust to blood levels and bleeding.
Usual dose in children
Congenital deficiency: usually 40 IU/kg intravenously every 28 days; dosing is guided by factor XIII levels and clinical need.
Common side effects
- Headache
- Injection-site reactions
- Fever
- Allergic reactions, rarely severe
Important warnings
- Given intravenously by trained healthcare professionals.
- Allergic reactions can occur; stop treatment and seek urgent care for severe symptoms.
- Antibodies against factor XIII may reduce treatment effectiveness.
- Use caution with previous reactions to plasma-derived products.
Pregnancy
Limited information; use when clearly needed, with specialist oversight.
Breastfeeding
Limited information; discuss use with the treating specialist.
Interactions
- No major drug interactions are well established.
- Tell clinicians about all medicines, especially other clotting products.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.