About evolocumab
PCSK9 cholesterol-lowering antibody
Used for
- Lowers LDL cholesterol in adults and children aged 10 years or older with inherited high cholesterol.
- Reduces cardiovascular risk in adults with established heart or blood-vessel disease.
Usual adult dose
140 mg injected under the skin every 2 weeks, or 420 mg monthly, alongside cholesterol-lowering treatment.
Usual dose in children
For inherited high cholesterol from age 10: 140 mg under the skin every 2 weeks, or 420 mg monthly.
Common side effects
- Runny nose, sore throat, or flu-like symptoms
- Back pain
- Injection-site reactions
- Allergic reactions, rarely severe
Important warnings
- Rare serious allergic reactions can occur.
- May be used with other cholesterol medicines; LDL levels should be monitored.
- The monthly dose requires three injections given consecutively or an approved dosing device.
Pregnancy
Human pregnancy data are limited; use during pregnancy requires weighing potential benefits and risks.
Breastfeeding
It is not known whether evolocumab passes into breast milk; discuss potential benefits and risks.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.