About estrogens + norgestrel
Estrogen-progestin hormone therapy
Used for
- Relief of moderate to severe menopausal hot flashes and vaginal symptoms
- Prevention of bone loss after menopause
Usual adult dose
Conjugated estrogens 0.625 mg daily with norgestrel 0.15 mg daily, taken in the prescribed sequential cycle.
Common side effects
- Breast tenderness, headache, nausea, or abdominal discomfort
- Irregular bleeding or spotting
- Fluid retention or mood changes
Important warnings
- Increases risk of blood clots, stroke, and certain cancers
- Not for preventing heart disease or dementia
- Avoid with unexplained vaginal bleeding, prior breast cancer, or active blood clots
- Estrogen can increase endometrial cancer risk unless paired with a progestin
Pregnancy
Not used during pregnancy; discontinue if pregnancy occurs.
Breastfeeding
Generally not used while breastfeeding; estrogen may reduce milk supply.
Interactions
- Some seizure medicines and rifampin can reduce hormone effects
- St. John’s wort may reduce hormone levels
- Thyroid replacement requirements may change
- Blood thinners may have altered effects
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.