About estradiol + norethisterone acetate
Combined estrogen-progestogen hormone therapy
Used for
- Relief of menopause symptoms, such as hot flushes and night sweats.
- Prevention of osteoporosis after menopause when other treatments are unsuitable.
Usual adult dose
One tablet once daily, taken continuously; dose depends on the prescribed product.
Common side effects
- Headache, breast tenderness, or nausea.
- Abdominal pain, bloating, or fluid retention.
- Irregular vaginal bleeding or spotting.
- Mood changes.
Important warnings
- Not for pregnancy or unexplained vaginal bleeding.
- Avoid with current or previous breast cancer, blood clots, or certain liver disease.
- Hormone therapy can increase risks of blood clots, stroke, and some cancers.
- Regular medical review is needed; use the lowest effective dose for the shortest time.
Pregnancy
Not used during pregnancy. Stop treatment if pregnancy occurs and seek medical advice.
Breastfeeding
Generally not used while breastfeeding; estrogen can reduce milk supply.
Interactions
- Some seizure, tuberculosis, and HIV medicines can reduce hormone levels.
- St John’s wort may reduce effectiveness.
- Some medicines may affect blood clotting or hormone levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.