About estradiol
Estrogen hormone replacement
Used for
- Relieves moderate to severe menopausal hot flashes and night sweats
- Treats vaginal and urinary symptoms of menopause
- Prevents bone loss after menopause
Usual adult dose
Apply one patch delivering 0.1 mg daily, usually changed twice weekly; dose depends on the condition treated.
Common side effects
- Breast tenderness or pain
- Headache
- Nausea or abdominal discomfort
- Skin irritation where the patch is applied
Important warnings
- If the uterus is present, a progestogen is usually needed to reduce uterine cancer risk.
- Estrogen can increase risks of blood clots, stroke, and certain cancers.
- Not for preventing heart disease or dementia.
- Avoid use with unexplained vaginal bleeding or a history of certain cancers or blood clots.
Pregnancy
Not used during pregnancy; discontinue if pregnancy occurs.
Breastfeeding
Generally avoided while breastfeeding because estrogen may reduce milk supply.
Interactions
- Some seizure medicines and rifampin can reduce estrogen levels.
- St. John's wort may reduce effectiveness.
- Estrogen can affect thyroid replacement requirements and some other medicines.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.