About estradiol
Estrogen hormone replacement therapy
Used for
- Relief of menopausal symptoms, such as hot flushes and vaginal dryness
- Prevention of osteoporosis after menopause when other treatments are unsuitable
Usual adult dose
Usually 1–2 mg once daily; dose depends on symptoms and treatment plan.
Common side effects
- Headache
- Breast tenderness
- Nausea
- Vaginal bleeding or spotting
Important warnings
- If the uterus is present, a progestogen is usually needed to protect the womb lining.
- Can increase risks of blood clots, stroke, and certain cancers; risks depend on treatment and personal factors.
- Seek urgent care for chest pain, sudden breathlessness, one-sided leg swelling, or stroke symptoms.
- Not a contraceptive; unexplained vaginal bleeding needs assessment.
Pregnancy
Do not use during pregnancy. Stop and contact a healthcare professional if pregnancy occurs.
Breastfeeding
Generally not used while breastfeeding; estrogen can reduce milk supply.
Interactions
- Some seizure medicines, rifampicin, and St John’s wort can reduce effects.
- Some HIV or hepatitis C medicines may alter estradiol levels.
- May affect medicines such as lamotrigine and thyroid hormone replacement.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.