About eplontersen
Transthyretin-directed antisense oligonucleotide
Used for
- Treats nerve damage caused by hereditary transthyretin amyloidosis in adults.
Usual adult dose
45 mg injected under the skin once monthly.
Common side effects
- Low vitamin A levels
- Vomiting
- Eye problems, including dry eyes
- Injection-site reactions
Important warnings
- Can lower vitamin A; supplementation is recommended during treatment.
- Seek urgent assessment for sudden vision changes or severe eye pain.
- Use caution with medicines affecting blood clotting; bleeding risk may increase.
Pregnancy
Human pregnancy information is limited. Low vitamin A can harm fetal development; excess vitamin A can also be harmful.
Breastfeeding
It is not known whether eplontersen passes into breast milk; effects on infants are unknown.
Interactions
- Vitamin A supplements: avoid amounts above the recommended daily allowance unless prescribed.
- Anticoagulants or antiplatelet medicines may increase bleeding risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.