About levodopa + carbidopa + entacapone
Dopamine replacement and COMT inhibitor combination
Used for
- Treats Parkinson’s disease symptoms in adults whose movement response fluctuates between doses.
Usual adult dose
One tablet at a time, matching the prescribed levodopa/carbidopa dose; take at intervals directed by a clinician. Maximum eight tablets daily.
Common side effects
- Involuntary movements
- Nausea or diarrhea
- Dizziness or low blood pressure
- Hallucinations or confusion
Important warnings
- May cause sleepiness or sudden sleep; avoid driving if affected.
- Do not stop abruptly; severe fever and muscle stiffness can occur.
- Can cause or worsen involuntary movements, hallucinations, or impulse-control problems.
- Urine, sweat, or saliva may become reddish-brown.
Pregnancy
Use only if clearly needed; human pregnancy information is limited.
Breastfeeding
May reduce breast-milk production; breastfeeding is generally not recommended during treatment.
Interactions
- Nonselective MAO inhibitors, such as phenelzine, are contraindicated.
- Iron supplements can reduce absorption; separate doses by at least two hours.
- May interact with blood-pressure medicines, antidepressants, and dopamine-blocking medicines.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.