About emapalumab lzsg
Interferon-gamma monoclonal antibody
Used for
- Treats primary hemophagocytic lymphohistiocytosis (HLH) in adults and children, including newborns.
- May be used with dexamethasone when HLH persists, returns, or cannot be treated with conventional therapy.
Usual adult dose
Initial 1 mg/kg intravenously twice weekly; dose may be increased based on response, up to 10 mg/kg.
Usual dose in children
Initial 1 mg/kg intravenously twice weekly; dose may be increased based on response, up to 10 mg/kg.
Common side effects
- Infections, including serious infections
- High blood pressure
- Infusion-related reactions
- Low potassium levels
Important warnings
- Serious infections can occur; assess for tuberculosis and other infections before treatment.
- Monitor for infections and infusion reactions during treatment.
- Vaccinations may need review; avoid live vaccines during treatment.
- Treatment requires specialist monitoring and may need dose adjustment.
Pregnancy
There are limited human data. Use during pregnancy only when the potential benefit justifies potential fetal risk.
Breastfeeding
It is unknown whether emapalumab passes into breast milk. Discuss breastfeeding with the treating clinician.
Interactions
- Avoid live vaccines during treatment.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.