About eluxadoline
Mixed opioid receptor agonist and antagonist
Used for
- Treats irritable bowel syndrome with diarrhea (IBS-D) in adults.
Usual adult dose
100 mg by mouth twice daily with food. A lower dose may be used for certain health conditions or intolerance.
Common side effects
- Constipation
- Nausea
- Abdominal pain
- Dizziness
Important warnings
- Can cause pancreatitis or sphincter of Oddi spasm, sometimes after the first dose.
- Do not use without a gallbladder, with bile duct problems, or with certain pancreatic disorders.
- Avoid with severe constipation, bowel obstruction, or a history of alcohol misuse.
- Rarely causes serious constipation; stop treatment if severe constipation develops.
Pregnancy
Available information is insufficient to determine pregnancy risks; use only when prescribed after weighing benefits and risks.
Breastfeeding
It is unknown whether eluxadoline passes into breast milk; discuss potential risks with a clinician.
Interactions
- Avoid with strong OATP1B1 inhibitors, such as cyclosporine; these can increase eluxadoline exposure.
- Avoid with other medicines that cause constipation, including opioids.
- Avoid with drugs that slow bowel movement, such as loperamide, except occasional use for acute diarrhea.
- Avoid with strong CYP1A2 inhibitors, such as fluvoxamine.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.