About eliglustat
Glucosylceramide synthase inhibitor
Used for
- Long-term treatment of adults with Gaucher disease type 1.
Usual adult dose
84 mg by mouth twice daily for most people; some people need 84 mg once daily based on metabolism and interacting medicines.
Common side effects
- Headache
- Dizziness
- Nausea
- Diarrhea or stomach pain
Important warnings
- Only for adults with Gaucher disease type 1.
- Dose depends on how the body processes the medicine and on other medicines taken.
- Can affect heart rhythm, especially with certain interacting medicines or heart conditions.
- Avoid in severe liver or kidney impairment, and in some moderate impairment with interacting medicines.
Pregnancy
Information is limited; use during pregnancy requires weighing potential benefits and risks.
Breastfeeding
It is not known whether eliglustat passes into breast milk; information on effects is limited.
Interactions
- Strong CYP2D6 or CYP3A inhibitors can raise eliglustat levels.
- CYP3A inducers can lower eliglustat levels and reduce effectiveness.
- Eliglustat can affect medicines metabolized by CYP2D6, including some antidepressants and beta blockers.
- Medicines that prolong the heart rhythm can increase risk of abnormal rhythm.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.