About elbasvir + grazoprevir
Direct-acting antiviral combination
Used for
- Treatment of chronic hepatitis C virus infection in adults, genotypes 1 or 4.
Usual adult dose
One tablet once daily for 12 weeks; some patients need 16 weeks with ribavirin.
Common side effects
- Headache
- Tiredness
- Nausea
- Increased liver enzymes
Important warnings
- Test for hepatitis B before treatment; reactivation can occur.
- Check liver function before and during treatment.
- Not for moderate or severe liver impairment.
- Resistance testing may guide treatment for genotype 1a.
Pregnancy
Pregnancy safety is not established; ribavirin, when used, can cause severe birth defects.
Breastfeeding
Whether the medicines pass into breast milk is unknown; effects on a nursing infant are uncertain.
Interactions
- Avoid strong CYP3A inducers, including rifampin and carbamazepine.
- Avoid certain HIV medicines, including atazanavir and efavirenz.
- May interact with statins, tacrolimus, and some heart-rhythm medicines.
- Ribavirin combination adds major pregnancy risks.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.