About elafibrano r
PPAR alpha/delta agonist
Used for
- Treats primary biliary cholangitis with ursodeoxycholic acid when response is inadequate.
- May be used alone when ursodeoxycholic acid is not tolerated.
Usual adult dose
80 mg by mouth once daily, with or without food.
Common side effects
- Weight gain
- Diarrhea
- Nausea
- Abdominal pain
Important warnings
- May cause muscle injury, especially with statins.
- Can cause or worsen gallstones and bile duct obstruction.
- Monitor liver tests; severe liver injury has occurred.
- Not recommended for decompensated cirrhosis.
Pregnancy
May cause fetal harm based on animal studies; human pregnancy data are limited.
Breastfeeding
Unknown whether elafibranor enters breast milk; discuss potential risks with a clinician.
Interactions
- Statins may increase muscle injury risk.
- Cyclosporine can increase elafibranor exposure.
- Rifampin may reduce elafibranor exposure.
- Bile acid sequestrants reduce absorption; separate doses by at least four hours.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.