About elacestrant dihydrochloride
Estrogen receptor antagonist
Used for
- Treats advanced or metastatic breast cancer with an ESR1 mutation.
- Used in adults after at least one hormone therapy.
Usual adult dose
345 mg by mouth once daily with food.
Common side effects
- Nausea, vomiting, or diarrhea
- High cholesterol or triglycerides
- Muscle or joint pain
- Fatigue or decreased appetite
Important warnings
- Can cause fetal harm; pregnancy testing is recommended before treatment.
- May raise cholesterol and triglycerides; monitoring is needed.
- Liver problems may require monitoring or dose changes.
- Avoid grapefruit and strong CYP3A4-interacting medicines.
Pregnancy
May cause fetal harm. Avoid during treatment and for one week after the final dose.
Breastfeeding
Do not breastfeed during treatment and for one week after the final dose.
Interactions
- Strong or moderate CYP3A4 inhibitors can increase drug levels.
- Strong or moderate CYP3A4 inducers can reduce effectiveness.
- Avoid grapefruit and grapefruit juice.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.