About edoxaban
Direct oral factor Xa anticoagulant
Used for
- Prevention of stroke and blood clots in non-valvular atrial fibrillation
- Treatment and prevention of recurrent deep vein thrombosis or pulmonary embolism
Usual adult dose
Atrial fibrillation: usually 60 mg once daily. DVT or pulmonary embolism: usually 60 mg once daily after at least five days of injectable anticoagulant; lower doses are used in some patients.
Common side effects
- Bleeding, including bruising or nosebleeds
- Anaemia
- Rash or itching
- Abdominal pain or nausea
Important warnings
- Can cause serious or fatal bleeding.
- Do not stop without medical direction; stopping can increase clot risk.
- Dose depends on kidney function, body weight, and certain medicines.
- Not suitable for some people with mechanical heart valves or active bleeding.
Pregnancy
Generally avoided during pregnancy because of bleeding risk; human safety information is limited.
Breastfeeding
Breastfeeding is generally not recommended during treatment; an alternative anticoagulant may be considered.
Interactions
- Other anticoagulants and antiplatelet medicines increase bleeding risk.
- NSAIDs, including ibuprofen and naproxen, may increase bleeding.
- Some antibiotics, antifungals, and HIV medicines can alter edoxaban levels.
- Rifampicin, carbamazepine, phenytoin, and St John’s wort may reduce its effect.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.