About duloxetine hydrochloride
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Used for
- Depression
- Generalized anxiety disorder
- Diabetic nerve pain
- Fibromyalgia and chronic musculoskeletal pain
Usual adult dose
Usually 30–60 mg once daily initially; common maintenance dose is 60 mg once daily, depending on condition.
Common side effects
- Nausea
- Dry mouth
- Dizziness
- Constipation
Important warnings
- Do not stop suddenly; withdrawal symptoms can occur.
- May increase suicidal thoughts, especially early in treatment or after dose changes.
- Can raise blood pressure and increase bleeding risk.
- Avoid with severe liver disease or heavy alcohol use.
Pregnancy
Use during pregnancy only when a clinician judges benefits outweigh risks; late-pregnancy use may affect the newborn.
Breastfeeding
Duloxetine enters breast milk in small amounts; discuss benefits and risks with a clinician.
Interactions
- MAO inhibitors: potentially dangerous interaction; avoid together.
- Other serotonergic medicines can cause serotonin syndrome.
- Blood thinners and NSAIDs may increase bleeding risk.
- Some medicines affecting CYP1A2 or CYP2D6 can alter duloxetine levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.