About drotrecogin alfa
Recombinant activated protein C anticoagulant
Used for
- Previously used for severe sepsis with a high risk of death; withdrawn from markets after studies found no survival benefit.
Usual adult dose
Historical dose: continuous intravenous infusion of 24 micrograms/kg/hour for 96 hours.
Common side effects
- Serious bleeding, including gastrointestinal or intracranial bleeding
- Bruising or other bleeding
Important warnings
- Withdrawn worldwide; not recommended for treatment.
- Historical use was contraindicated with active bleeding or high bleeding risk.
Pregnancy
Pregnancy safety is unknown; the medicine is withdrawn and has no established role in pregnancy.
Breastfeeding
Effects on breastfeeding are unknown; the medicine is withdrawn and has no established role during breastfeeding.
Interactions
- Anticoagulants and antiplatelet medicines may increase bleeding risk.
- Other medicines that impair clotting may increase bleeding risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.