About doxepin hydrochloride
Tricyclic antidepressant
Used for
- Depression and anxiety disorders
- Short-term relief of itching from eczema or other skin conditions
Usual adult dose
Depression or anxiety: usually 75–150 mg daily, adjusted by a prescriber. Skin itching: doses vary by product and condition.
Common side effects
- Sleepiness, dizziness, and dry mouth
- Constipation, blurred vision, or difficulty urinating
- Weight gain or increased appetite
- Low blood pressure or abnormal heart rhythm
Important warnings
- Can cause suicidal thoughts, especially early in treatment or after dose changes.
- Avoid alcohol and driving if sleepy; overdose can be life-threatening.
- Use caution with glaucoma, urinary problems, heart disease, or seizure disorders.
- Do not stop suddenly without medical guidance.
Pregnancy
Use only when the expected benefit outweighs potential risks; discuss with a healthcare professional.
Breastfeeding
Doxepin may harm or sedate a nursing infant; generally avoid during breastfeeding.
Interactions
- Monoamine oxidase inhibitors: dangerous interactions; allow at least 14 days between treatments.
- Other sedatives, opioids, or alcohol can increase drowsiness and breathing risks.
- Medicines that affect serotonin can increase serotonin syndrome risk.
- Some medicines raise doxepin levels or increase heart-rhythm risks.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.